PO (Geriatric Patients) mg/day in divided doses initially; may beqq 3 – 4 days. Insomnia. PO (Adults) – mg at bedtime. NURSING IMPLICATIONS. Assessment. ○ Monitor BP and pulse rate before and during initial therapy. Monitor ECGs in pa- tients with pre-existing cardiac disease before and periodically during. TRAZODONE HYDROCHLORIDE (tray'zoe-done) Desyrel, Desyrel Dividose Classifications: central nervous system (cns) agent; psychotherapeutic agent; antidepressant. Prototype: Imipramine Pregnancy Category: C.
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Distribution: Distributed into breast milk. Metabo- lism: In liver (CYP2D6). Elimina- tion: 75% in urine, 25% in feces. Half-Life: 5–9 h. NURSING IMPLICATIONS. Black Box Warning Trazodone hydrochloride has been associated with suicidal thinking and behavior in children, adolescents, and young adults. DOSING CONSIDERATIONS. Hepatic Impairment. Patients with hepatic dysfunction may require dosage adjustment of trazodone based upon the severity of hepatic impairment as trazodone is extensively metabolized, however, no quantitative guidelines are available. Titrate according to patient response and tolerance;.
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